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Parkinsons-Dementia - Parkinsons-Dementia Symptom, Cause, Treatment
Parkinson's disease (PD) is one of the most common neurodegenerative movement disorder, which affects about 1% of the population over age 60. Although Parkinson's disease has a number of key features that are similar to Alzheimer's disease. Although the results seen in the 24-week EXPRESS study are not overwhelming, they appear to be similar in magnitude to those seen in Alzheimer's patients, and suggest that AChE inhibitors could offer clinically significant advantages in this population, experts say. In patients with Dementia with Lewy bodies (DLB) , dementia is the central feature of the disease. The overlap of clinical symptoms between PDD and DLB suggest that they probably represent different points on a spectrum of lewy body diseases sharing similar underlying processes. Rivastigmine differs from other AChE inhibitors in that it additionally inhibits butylrylcholinesterase, which is also involved in the breakdown of the neurotransmitter, acetylcholine Dopamine transports the signals to the part of the brain that controls movement, coordination and initiation. Although none of these tests actually diagnose Parkinson's disease, they may reveal the presence of some other conditions that could be responsible for the symptoms
Symptoms of Parkinsons-Dementia
Some are common symptoms of Parkinsons-Dementia :
- This can be problems sleep patterns, insomnia, early morning wakening,sleeping too much
- Symptoms of Parkinson's, which often appear gradually yet with increasing severity, may include tremors or trembling; difficulty maintaining balance and gait; rigidity or stiffness of the limbs and trunk; and general slowness of movement (also called bradykinesia).
- Increased problems with concentration, ability to think
- Tremor of the hands, arms, legs, jaw, and face
- Marked loss of interest or pleasure in activities
- We demonstrate that dementia progression and specific aetiologies have characteristic patterns of decline and destruction from the strong synergy that exists between symptoms and signs among the population with no cognitive impairment.
- Impaired balance and/or coordination
Causes of Parkinsons-Dementia
The common causes of Parkinsons-Dementia :
- Scientists have not yet found the exact cause of Parkinson's disease.
- Most people researching the disease agree that there are probably multiple factors that contribute to someone getting Parkinson's.
- Some studies have found though, that those who have experienced a head injury are four times more likely to develop PD than those who have never suffered a head injury.
- An example is that glucomate may be implicated in cell death. Mitochondrial dysfunction.
- A gene being transmitted via an autosomal dominant trait.
15-25% of people with Parkinson's disease have a relative with the disease.
Treatment of Parkinsons-Dementia
- Anticholinergics (trihexyphenidyl, benztropine mesylate, procyclidine, etc.)
- Combining Levodopa with Carbidopa
- Deep brain stimulation (DBS) is a surgical procedure used to treat a variety of disabling neurological symptoms and the commonly the debilitating symptoms of Parkinson's disease
- This surgical procedure destroys part of the thalamus, a part of the brain involved in movement control.
- Levodopa - a dopamine precursor
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